Article
Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia.
Nature genetics - 1 Feb 2013
De Keersmaecker Kim, Atak Zeynep Kalender, Li Ning, Vicente Carmen, Patchett Stephanie, Girardi Tiziana, Gianfelici Valentina, Geerdens Ellen, Clappier Emmanuelle, Porcu Michaël, Lahortiga Idoya, Lucà Rossella, Yan Jiekun, Hulselmans Gert, Vranckx Hilde, Vandepoel Roel, Sweron Bram, Jacobs Kris, Mentens Nicole, Wlodarska Iwona, Cauwelier Barbara, Cloos Jacqueline, Soulier Jean, Uyttebroeck Anne, Bagni Claudia, Hassan Bassem A, Vandenberghe Peter, Johnson Arlen W, Aerts Stein, Cools Jan
Abstract excerpt
T-cell acute lymphoblastic leukemia (T-ALL) is caused by the cooperation of multiple oncogenic lesions. We used exome sequencing on 67 T-ALLs to gain insight into the mutational spectrum in these leukemias. We detected protein-altering mutations in 508 genes, with an average of 8.2 mutations in pediatric and 21.0 mutations in adult T-ALL. Using stringent filtering, we predict seven new oncogenic driver genes in...
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