Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of Molecular Subtypes of B-Cell Acute Lymphoblastic Leukemia in Mexican Children by Whole-Transcriptome Analysis.

International journal of molecular sciences - 21 Jul 2025

Sánchez-Escobar Norberto, Romero-Tlalolini María de Los Ángeles, Rosas-Vargas Haydeé, Jiménez-Hernández Elva, Núñez Enríquez Juan Carlos, Rangel-López Angélica, Sánchez López José Manuel, Rojo-Serrato Daniela, Jasso Mata América Mariana, Márquez Aguilar Efraín Abimael, Flores-Lujano Janet, Bravata-Alcántara Juan Carlos, Martín-Trejo Jorge Alfonso, Jiménez-Morales Silvia, Arellano-Galindo José, Sanson Aurora Medina, Gonzalez Jose Gabriel Peñaloza, Mejía-Aranguré Juan Manuel, Mata-Rocha Minerva

Abstract excerpt

B-lineage acute lymphoblastic leukemia (B-ALL) is classified into more than 20 molecular subtypes, and next-generation sequencing has facilitated the identification of these with high sensitivity. Bulk RNA-seq analysis of bone marrow was realized to identify molecular subtypes in Mexican pediatric patients with B-ALL. High hyperdiploidy (27.3%) was the most frequent molecular subtype, followed by DUX4 (13.6%),...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Child, Preschool

Share to Gene Expression Profiling

Share to Infant

Share to Mexico

Share to Precursor B-Cell Lymphoblastic Leukemia-Lymphoma

Share to Transcriptome

Source

Open in PubMed Open full text

Identifiers

PMID: 40725249
DOI: 10.3390/ijms26147003
PMCID: PMC12295331

Genes

DUX4
ETV6
JAK2
NRAS
RUNX1
TCF3
ADGRF1
BCR
CRLF2
FLT3
KMT2A
NT5C2
PBX1
RAG1
SEMA6A
SETD2
SPATS2L
STAT2
TYK2
ZNF384

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of Molecular Subtypes of B-Cell Acute Lymphoblastic Leukemia in Mexican Children by Whole-Transcriptome Analysis.PMID 40725249Read ↗

Molecular Characterization of Pediatric B-cell Acute Lymphoblastic Leukemia using Integrative Transcriptomics: A Multicenter Study in ArgentinaSemantic proximity Read ↗

Emerging molecular subtypes and therapeutic targets in B-cell precursor acute lymphoblastic leukemia.Semantic proximity Read ↗

Whole-transcriptome analysis in acute lymphoblastic leukemia: a report from the DFCI ALL Consortium Protocol 16-001Semantic proximity Read ↗

Whole genome sequencing provides comprehensive genetic testing in childhood B-cell acute lymphoblastic leukaemiaSemantic proximity Read ↗

Whole genome sequencing provides comprehensive genetic testing in childhood B-cell acute lymphoblastic leukaemiaSemantic proximity Read ↗

The application of RNA sequencing for the diagnosis and genomic classification of pediatric acute lymphoblastic leukemiaSemantic proximity Read ↗

Multi-Cohort Transcriptomic Subtyping of B-Cell Acute Lymphoblastic LeukemiaSemantic proximity Read ↗

Transcriptional landscape of B cell precursor acute lymphoblastic leukemia based on an international study of 1,223 casesSemantic proximity Read ↗

Genetic subtypes of B-cell acute lymphoblastic leukemia in adultsSemantic proximity Read ↗

Identification of Novel Fusion Genes in Pediatric B-ALL patients Using Whole Transcriptome SequencingSemantic proximity Read ↗

Oncogenic lesions and molecular subtypes in adults with B-cell acute lymphoblastic leukemia.Semantic proximity Read ↗

Deep targeted sequencing in pediatric acute lymphoblastic leukemia unveils distinct mutational patterns between genetic subtypes and novel relapse-associated genes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.