Diagnostic utility of whole genome sequencing in adults with B-other acute lymphoblastic leukemia.

doi:10.1182/bloodadvances.2022008992

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Diagnostic utility of whole genome sequencing in adults with B-other acute lymphoblastic leukemia.

Blood advances - 8 Aug 2023

Leongamornlert Daniel, Gutiérrez-Abril Jesús, Lee SooWah, Barretta Emilio, Creasey Thomas, Gundem Gunes, Levine Max F, Arango-Ossa Juan E, Liosis Konstantinos, Medina-Martinez Juan S, Zuborne Alapi Krisztina, Kirkwood Amy A, Clifton-Hadley Laura, Patrick Pip, Jones David, O'Neill Laura, Butler Adam P, Harrison Christine J, Campbell Peter, Patel Bela, Moorman Anthony V, Fielding Adele K, Papaemmanuil Elli

Abstract excerpt

Genomic profiling during the diagnosis of B-cell precursor acute lymphoblastic leukemia (BCP-ALL) in adults is used to guide disease classification, risk stratification, and treatment decisions. Patients for whom diagnostic screening fails to identify disease-defining or risk-stratifying lesions are classified as having B-other ALL. We screened a cohort of 652 BCP-ALL cases enrolled in UKALL14 to identify and...

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PMID: 36867579
DOI: 10.1182/bloodadvances.2022008992
PMCID: PMC10405200

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