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Article

The Impact of p53 on Aristolochic Acid I-Induced Gene Expression In Vivo.

International journal of molecular sciences - 6 Dec 2019

Sborchia Mateja, Keun Hector C, Phillips David H, Arlt Volker M

Abstract excerpt

Exposure to aristolochic acid (AA) is linked to kidney disease and urothelial cancer in humans. The major carcinogenic component of the AA plant extract is aristolochic acid I (AAI). The tumour suppressor p53 is frequently mutated in AA-induced tumours. We previously showed that p53 protects from AAI-induced renal proximal tubular injury, but the underlying mechanism(s) involved remain to be further explored. In...

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Identifiers

PMID: 31817608
DOI: 10.3390/ijms20246155
PMCID: PMC6940885

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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