Article
Role of p53 gene in apoptotic repair of genotoxic tissue damage in mice.
Journal of radiation research - 1 Dec 2002
Kato Fumio, Kakihara Hiroyo, Kunugita Naoki, Ootsuyama Akira, Norimura Toshiyuki
Abstract excerpt
When DNA is damaged by exposure to a small amount of radiation, it is repaired efficiently by innate mechanisms. However, if cellular damage is more extensive, DNA repair cannot be adequately completed. To clarify the role of the p53 gene in apoptotic tissue repair, the incidence of in-vivo radiation-induced somatic mutation was evaluated by measuring the T cell receptor (TCR) gene expression in p53(+/+) and...
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