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The impact of p53 on aristolochic acid I-induced nephrotoxicity and DNA damage in vivo and in vitro

10 Oct 2019

Abstract excerpt

Abstract Exposure to aristolochic acid (AA) is associated with human nephropathy and urothelial cancer. The tumour suppressorTP53is a critical gene in carcinogenesis and frequently mutated in AA-induced urothelial tumours. We investigated the impact of p53 on AAI-induced nephrotoxicity and DNA damage in vivo by treatingTrp53(+/+),Trp53(+/−) andTrp53(−/−) mice with 3.5 mg/kg body weight (bw) AAI daily for 2 or 6...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 31602497
DOI: 10.1007/s00204-019-02578-4

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