Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of p53 in the progression from ochratoxin A-induced DNA damage to gene mutations in the kidneys of mice.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Mar 2015

Kuroda Ken, Hibi Daisuke, Ishii Yuji, Yokoo Yuh, Takasu Shinji, Kijima Aki, Matsushita Kohei, Masumura Ken-ichi, Kodama Yukio, Yanai Tokuma, Sakai Hiroki, Nohmi Takehiko, Ogawa Kumiko, Umemura Takashi

Abstract excerpt

Carcinogenic doses of ochratoxin A (OTA) cause increases of mutant frequencies (MFs) of the red/gam gene (Spi(-)) in the kidneys of p53-deficient gpt delta mice, but not in p53-proficient mice. Here, we investigated the role of p53 in the progression from OTA-induced DNA damage to gene mutations....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Comet Assay
Share to Cyclin-Dependent Kinase Inhibitor p21

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Breaks, Double-Stranded

Share to Enzyme-Linked Immunosorbent Assay

Share to G1 Phase Cell Cycle Checkpoints

Share to Histones

Share to Kidney

Share to Kidney Neoplasms

Source

Identifiers

PMID: 25636497
DOI: 10.1093/toxsci/kfu267

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25636497-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of p53 in the progression from ochratoxin A-induced DNA damage to gene mutations in the kidneys of mice.PMID 25636497Read ↗

Effects of p53 knockout on ochratoxin A-induced genotoxicity in p53-deficient gpt delta mice.Semantic proximity Read ↗

Analysis of TP53 mutation spectra reveals the fingerprint of the potent environmental carcinogen, aristolochic acid.Semantic proximity Read ↗

Ochratoxin A-induced mutagenesis in mammalian cells is consistent with the production of oxidative stress.Semantic proximity Read ↗

The impact of p53 on aristolochic acid I-induced nephrotoxicity and DNA damage in vivo and in vitroSemantic proximity Read ↗

The Impact of p53 on Aristolochic Acid I-Induced Gene Expression In Vivo.Semantic proximity Read ↗

The role of nucleotide excision repair and loss of p53 in mutagenesis and carcinogenesis.Semantic proximity Read ↗

Mutant frequency in comparison to oxidative DNA damage induced by ochratoxin A in L5178Y tk+/- (3.7.2C) mouse lymphoma cells.Semantic proximity Read ↗

Combined application of comprehensive analysis for DNA modification and reporter gene mutation assay to evaluate kidneys of gpt delta rats given madder color or its constituents.Semantic proximity Read ↗

Gene expression changes induced by the human carcinogen aristolochic acid I in renal and hepatic tissue of miceSemantic proximity Read ↗

Role of p53 gene in apoptotic repair of genotoxic tissue damage in mice.Semantic proximity Read ↗

Sex- and strain-specific expression of cytochrome P450s in Ochratoxin A-induced genotoxicity and carcinogenicity in ratsSemantic proximity Read ↗

Deletion and single nucleotide substitution at G:C in the kidney of gpt delta transgenic mice after ferric nitrilotriacetate treatment.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.