Article
Heavy-ion-induced mutations in the gpt delta transgenic mouse: effect of p53 gene knockout.
Environmental and molecular mutagenesis - 1 Jan 2002
Yatagai Fumio, Kurobe Toshihiro, Nohmi Takehiko, Masumura Ken-ichi, Tsukada Teruyo, Yamaguchi Hirotake, Kasai-Eguchi Kiyomi, Fukunishi Nobuhisa
Abstract excerpt
The influence of the loss of p53 gene on heavy-ion-induced mutations was examined by constructing a new line of transgenic mice, p53 knockout (p53(-/-)) gpt delta. In this mouse model, deletions in lambda DNA integrated into the mouse genome are preferentially selected as Spi(-) phages, which can then be subjected to molecular analysis. Mice were exposed to 10 Gy of whole-body carbon-ion irradiation. The carbon...
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