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Article

Human and rodent aldo-keto reductases from the AKR1B subfamily and their specificity with retinaldehyde.

Chemico-biological interactions - 30 May 2011

Ruiz F Xavier, Moro Armando, Gallego Oriol, Ardèvol Albert, Rovira Carme, Petrash J Mark, Parés Xavier, Farrés Jaume

Abstract excerpt

NADP(H)-dependent cytosolic aldo-keto reductases (AKR) are mostly monomeric enzymes which fold into a typical (α/β)(8)-barrel structure. Substrate specificity and inhibitor selectivity are determined by interaction with residues located in three highly variable loops (A, B, and C). Based on sequence identity, AKR have been grouped into families, namely AKR1-AKR15, containing multiple subfamilies. Two human...

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Identifiers

PMID: 21329680
DOI: 10.1016/j.cbi.2011.02.007
PMCID: PMC3103653

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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