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Article

Functional characterization of genetic variations in the MDR3 promoter.

Biochemical and biophysical research communications - 25 Jan 2013

Jang Geun Hye, Kim Tae Hee, Choe Yunseo, Ham Ahrong, Choi Ji Ha

Abstract excerpt

Multidrug resistance 3 (MDR3) is present on the canalicular membrane of the hepatocyte and plays an important role in protecting the liver from bile acids. In this study, we characterized the transcriptional effects of four common haplotypes and four polymorphic variants in the promoter region of MDR3 that were identified in 126 DNA samples from Koreans. We measured the luciferase activities of the four MDR3...

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PMID: 23261441
DOI: 10.1016/j.bbrc.2012.12.041

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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