Article
A functional promoter polymorphism of IFITM3 is associated with susceptibility to pediatric tuberculosis in Han Chinese population.
PloS one - 1 Jan 2013
Shen Chen, Wu Xi-rong, Jiao Wei-wei, Sun Lin, Feng Wei-xing, Xiao Jing, Miao Qing, Liu Fang, Yin Qing-qin, Zhang Chen-guang, Guo Ya-jie, Shen A-dong
Abstract excerpt
A susceptibility locus for tuberculosis, a re-emerging infectious disease throughout the world, was previously discovered to exist on chromosome 11p15. IFITM3 gene encoding for interferon inducible transmembrane protein 3, is located at 11p15. It acts as an effector molecule for interferon-gamma, which is essential for anti-tuberculosis immune response. In order to investigate the association between...
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