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Article

Identification of the promoter of human carbonyl reductase 3 (CBR3) and impact of common promoter polymorphisms on hepatic CBR3 mRNA expression.

Pharmaceutical research - 1 Sept 2009

Zhang Jianping, Blanco Javier G

Abstract excerpt

PURPOSE: Recent studies suggest that polymorphisms in human carbonyl reductase 3 (CBR3) influence the pharmacodynamics of doxorubicin. First, we sought to identify the promoter of CBR3. Next, we examined whether two CBR3 promoter polymorphisms (CBR3 -725T>C and CBR3 -326T>A) dictate promoter activity and hepatic CBR3 mRNA levels. METHODS: The promoter activities of CBR3 reporter constructs were investigated in...

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Identifiers

PMID: 19590938
DOI: 10.1007/s11095-009-9936-9
PMCID: PMC3368600

Genes

CBR3

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