Measuring inorganic phosphate and intracellular pH in the healthy and hypertrophic cardiomyopathy hearts by in vivo 7T 31P-cardiovascular magnetic resonance spectroscopy

Abstract excerpt

Cardiovascular phosphorus MR spectroscopy ( 31 P-CMRS) is a powerful tool for probing energetics in the human heart, through quantification of phosphocreatine (PCr) to adenosine triphosphate (ATP) ratio. In principle, 31 P-CMRS can also measure cardiac intracellular pH (pH i ) and the free energy of ATP hydrolysis (ΔG ATP ). However, these require determination of the inorganic phosphate (Pi) signal frequency and...

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