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Article

The von Hippel-Lindau Chuvash mutation in mice alters cardiac substrate and high-energy phosphate metabolism.

American journal of physiology. Heart and circulatory physiology - 1 Sept 2016

Slingo Mary, Cole Mark, Carr Carolyn, Curtis Mary K, Dodd Michael, Giles Lucia, Heather Lisa C, Tyler Damian, Clarke Kieran, Robbins Peter A

Abstract excerpt

Hypoxia-inducible factor (HIF) appears to function as a global master regulator of cellular and systemic responses to hypoxia. HIF pathway manipulation is of therapeutic interest; however, global systemic upregulation of HIF may have as yet unknown effects on multiple processes. We used a mouse model of Chuvash polycythemia (CP), a rare genetic disorder that modestly increases expression of HIF target genes in...

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Identifiers

PMID: 27422990
DOI: 10.1152/ajpheart.00912.2015
PMCID: PMC5142182

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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