Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association between SMAD3 gene rs12901499 polymorphism and knee osteoarthritis in a Chinese population.

Journal of clinical laboratory analysis - 1 Jun 2018

Zhang Li, Zhang Limin, Zhang Haiqin, Wang Wenjun, Zhao You

Abstract excerpt

BACKGROUND: Many studies have revealed that transforming growth factor-beta (TGF-β) signals play important roles in maintaining normal status of articular cartilage in human osteoarthritis (OA). However, SMAD3 had inhibitory effect on TGF-β-induced chondrocyte maturation. METHOD: To evaluate the association of SMAD3 genetic variants with the risk of knee OA, we conducted this hospital-based case-control study...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age Factors
Share to Asian People
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Association Studies

Share to Logistic Models

Share to Osteoarthritis, Knee

Share to Polymorphism, Single Nucleotide

Share to Smad3 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 29315792
DOI: 10.1002/jcla.22383
PMCID: PMC6817063

Genes

SMAD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association between SMAD3 gene rs12901499 polymorphism and knee osteoarthritis in a Chinese population.PMID 29315792Read ↗

Association between SMAD3 gene polymorphisms and osteoarthritis risk: a systematic review and meta-analysis.Semantic proximity Read ↗

The Role Of Rs12901499 Polymorphism In Association With Smad3 Gene And Osteoarthritis Susceptibility: Systematic Review And Meta-Analysis.Semantic proximity Read ↗

SMAD3 gene rs12901499 polymorphism increased the risk of osteoarthritis.Semantic proximity Read ↗

Genetic variation of SMAD3 is associated with hip osteoarthritis in a Chinese Han population.Semantic proximity Read ↗

Genetic variation in the SMAD3 gene is associated with hip and knee osteoarthritis.Semantic proximity Read ↗

A SMAD3 gene polymorphism is related with osteoarthritis in a Northeast Chinese population.Semantic proximity Read ↗

Gene-gene interactions between TGF-β/Smad3 signalling pathway polymorphisms affect susceptibility to knee osteoarthritis.Semantic proximity Read ↗

Association between the interaction of SMAD3 polymorphisms with body mass index and osteoarthritis susceptibility.Semantic proximity Read ↗

Association study of the functional variants of the GLIS3 gene with risk of knee osteoarthritis.Semantic proximity Read ↗

Association between transforming growth factor-beta 1 gene single nucleotide polymorphisms and knee osteoarthritis susceptibility in a Chinese Han population.Semantic proximity Read ↗

Association between growth differentiation factor 5 rs143383 genetic polymorphism and the risk of knee osteoarthritis among Caucasian but not Asian: a meta-analysis.Semantic proximity Read ↗

Association of GDF5, SMAD3 and RUNX2 polymorphisms with temporomandibular joint osteoarthritis in female Han Chinese.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.