Article
CYP3A4*22: promising newly identified CYP3A4 variant allele for personalizing pharmacotherapy.
Pharmacogenomics - 1 Jan 2013
Elens Laure, van Gelder Teun, Hesselink Dennis A, Haufroid Vincent, van Schaik Ron H N
Abstract excerpt
Many studies have attempted to explain the interindividual variability observed in drug metabolism by assessing the impact of SNPs in genes implicated in drug absorption, distribution, metabolism and excretion pathways. Particular attention has been paid to the CYP450s. CYP3A4 is the main CYP isoform in human liver and intestine and is involved in the metabolism of many drugs. Its activity, however, is...
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