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CYP3A4∗22 Genotyping in Clinical Practice: Ready for Implementation?

8 Jul 2021

Abstract excerpt

Cytochrome P450 3A4 (CYP3A4) is the most important drug metabolizing enzyme in the liver, responsible for the oxidative metabolism of ∼50% of clinically prescribed drugs. Therefore, genetic variation inCYP3A4could potentially affect the pharmacokinetics, toxicity and clinical outcome of drug treatment. Thus far, pharmacogenetics for CYP3A4 has not received much attention. However, the recent discovery of the...

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PMID: 34306041
DOI: 10.3389/fgene.2021.711943

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