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Article

Potential role of IFNα in adult lupus.

Arthritis research & therapy - 1 Jan 2010

Rönnblom Lars

Abstract excerpt

Patients with lupus have a continuous production of IFNα and display an increased expression of IFNα-regulated genes. The reason for the ongoing IFNα synthesis in these patients seems to be an activation of plasmacytoid dendritic cells (pDCs) by immune complexes (ICs), consisting of autoantibodies in combination with DNA-containing or RNA-containing autoantigens. The mechanisms behind the activation of pDCs by...

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Identifiers

PMID: 20392290
DOI: 10.1186/ar2884
PMCID: PMC2991776

Genes

STAT4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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