Circulating Toll-like receptor and cytokine profiles and genetic polymorphisms in a Chinese sepsis cohort: potential links to neuroinflammation and blood-brain barrier dysfunction.

Abstract excerpt

Background: Sepsis is characterised by a dysregulated host response to infection and remains a major cause of morbidity and mortality. Toll-like receptor (TLR)-mediated inflammatory signalling can amplify systemic cytokine release and has been implicated in sepsis-associated brain dysfunction through neuroinflammation and blood-brain barrier (BBB) impairment. This study examined circulating TLR/cytokine profiles...

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