Article
Active site mutations in mammalian DNA polymerase delta alter accuracy and replication fork progression.
The Journal of biological chemistry - 15 Oct 2010
Schmitt Michael W, Venkatesan Ranga N, Pillaire Marie-Jeanne, Hoffmann Jean-Sébastien, Sidorova Julia M, Loeb Lawrence A
Abstract excerpt
DNA polymerase δ (pol δ) is one of the two main replicative polymerases in eukaryotes; it synthesizes the lagging DNA strand and also functions in DNA repair. In previous work, we demonstrated that heterozygous expression of the pol δ L604G variant in mice results in normal life span and no apparent phenotype, whereas a different substitution at the same position, L604K, is associated with shortened life span and...
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