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Article

Identification of functional DNA variants in the constitutive promoter region of MDM2.

Human genomics - 1 Sept 2012

Lalonde Marie-Eve, Ouimet Manon, Larivière Mathieu, Kritikou Ekaterini A, Sinnett Daniel

Abstract excerpt

Although mutations in the oncoprotein murine double minute 2 (MDM2) are rare, MDM2 gene overexpression has been observed in several human tumors. Given that even modest changes in MDM2 levels might influence the p53 tumor suppressor signaling pathway, we postulated that sequence variation in the promoter region of MDM2 could lead to disregulated expression and variation in gene dosage. Two promoters have been...

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Identifiers

PMID: 23244604
DOI: 10.1186/1479-7364-6-15
PMCID: PMC3500213

Genes

MDM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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