Article
SNP55, a new functional polymorphism of MDM2-P2 promoter, contributes to allele-specific expression of MDM2 in endometrial cancers.
BMC medical genetics - 21 Aug 2015
Okamoto Kanako, Tsunematsu Ryosuke, Tahira Tomoko, Sonoda Kenzo, Asanoma Kazuo, Yagi Hiroshi, Yoneda Tomoko, Hayashi Kenshi, Wake Norio, Kato Kiyoko
Abstract excerpt
BACKGROUND: The functional single nucleotide polymorphism (SNP) in the MDM2 promoter region, SNP309, is known to be associated with various diseases, particularly cancer. Although many studies have been performed to demonstrate the mechanism of allele-specific expression (ASE) on SNP309, they have only utilized in vitro techniques. It is unknown whether ASE of MDM2 is ascribed solely to SNP309, in vivo. METHODS:...
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