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Article

Genetic variants in the MDM2 promoter and lung cancer risk in a Chinese population.

International journal of cancer - 1 Mar 2006

Hu Zhibin, Ma Hongxia, Lu Daru, Qian Ji, Zhou Jiannong, Chen Yijiang, Xu Lin, Wang Xinru, Wei Qingyi, Shen Hongbing

Abstract excerpt

Overexpression of MDM2 may attenuate the P53 stress response pathway through direct blocking of P53 transcriptional activity and mediating P53 degradation. Two promoter polymorphisms (one is a T to G substitution at the intronic P53-response promoter, and the other is a 40-bp insertion/deletion p...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16152608
DOI: 10.1002/ijc.21463

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16152608-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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