A 40-bp insertion/deletion polymorphism in the constitutive promoter of MDM2 confers risk for hepatocellular carcinoma in a Chinese population.

doi:10.1016/j.gene.2012.01.004

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

A 40-bp insertion/deletion polymorphism in the constitutive promoter of MDM2 confers risk for hepatocellular carcinoma in a Chinese population.

Gene - 10 Apr 2012

Dong Dong, Gao Xueren, Zhu Zhansheng, Yu Qiang, Bian Shizhong, Gao Yuzhen

Abstract excerpt

The pathogenesis of HCC is a multistage process with the involvement of genetic factors. The aim of the present study is to investigate the possible association between a 40-bp insertion/deletion polymorphism (indel) at constitutive promoter of MDM2 and risk of hepatocellular carcinoma (HCC) in a Chinese population. Using 420 HCC patients and 423 control subjects, we genotyped the indel polymorphism (rs3730485)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha-Fetoproteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Asian People

Share to Carcinoma, Hepatocellular

Share to INDEL Mutation

Share to Liver Neoplasms

Share to Promoter Regions, Genetic

Share to Proto-Oncogene Proteins c-mdm2

Share to Risk

Source

Open in PubMed

Identifiers

PMID: 22285926
DOI: 10.1016/j.gene.2012.01.004

Genes

MDM2
AFP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A 40-bp insertion/deletion polymorphism in the constitutive promoter of MDM2 confers risk for hepatocellular carcinoma in a Chinese population.PMID 22285926Read ↗

MDM2 promoter polymorphism is associated with increased susceptibility to hepatocellular carcinoma in Turkish population.Semantic proximity Read ↗

Association between MDM2-SNP309 and hepatocellular carcinoma in Taiwanese population.Semantic proximity Read ↗

MDM2 (T309G) Gene Polymorphism Determines the Susceptibility of Hepatocellular Carcinoma in BangladeshSemantic proximity Read ↗

MDM2 SNP309T>G polymorphism with hepatocellular carcinoma risk: a meta-analysis.Semantic proximity Read ↗

MDM2 SNP309T>G polymorphism increases susceptibility to hepatitis B virus-related hepatocellular carcinoma in a northeast Han Chinese population.Semantic proximity Read ↗

MDM2 promoter SNP309 is associated with the risk of hepatocellular carcinoma in patients with chronic hepatitis C.Semantic proximity Read ↗

A 40-bp insertion/deletion polymorphism of Murine Double Minute2 (MDM2) increased the risk of breast cancer in Zahedan, Southeast Iran.Semantic proximity Read ↗

MDM2 SNP309T>G polymorphism and hepatocellular carcinoma risk: a meta-analysis.Semantic proximity Read ↗

Association between MDM2 SNP309, p53 Arg72Pro, and hepatocellular carcinoma risk: A MOOSE-compliant meta-analysis.Semantic proximity Read ↗

Identification of functional DNA variants in the constitutive promoter region of MDM2.Semantic proximity Read ↗

Results based on 124 cases of breast cancer and 97 controls from Taiwan suggest that the single nucleotide polymorphism (SNP309) in the MDM2 gene promoter is associated with earlier onset and increased risk of breast cancer.Semantic proximity Read ↗

Association of Single Nucleotide Polymorphisms of the MDM4 Gene With the Susceptibility to Breast Cancer in a Southeast Iranian Population Sample.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.