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Article

A functional p53-responsive intronic promoter is contained within the human<i>mdm2</i>gene

1 Jan 1995

Abstract excerpt

The mdm2 gene is a target for transcriptional activation by the p53 tumor suppressor gene product. Previous work has revealed that the mouse mdm2 gene contains two promoters: one is located upstream to the gene and is active in the absence of p53, the other resides within the first intron and requires p53 for transcriptional activity. To determine whether this unique promoter activation pattern is biologically...

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PMID: 7651818
DOI: 10.1093/nar/23.14.2584

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