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Article

A chromatin-associated and transcriptionally inactive p53-Mdm2 complex occurs in mdm2 SNP309 homozygous cells.

The Journal of biological chemistry - 22 Jul 2005

Arva Nicoleta C, Gopen Tamara R, Talbott Kathryn E, Campbell Latoya E, Chicas Agustin, White David E, Bond Gareth L, Levine Arnold J, Bargonetti Jill

Abstract excerpt

In cancer cells, the function of the tumor suppressor protein p53 is usually blocked. Impairment of the p53 pathway results in tumor cells with endogenous overexpression of Mdm2 via a naturally occurring single nucleotide polymorphism (SNP) in the mdm2 gene at position 309. Here we report that in...

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Source

Identifiers

PMID: 15908423
DOI: 10.1074/jbc.M505203200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15908423-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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A chromatin-associated and transcriptionally inactive p53-Mdm2 complex occurs in mdm2 SNP309 homozygous cells.PMID 15908423Read ↗

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