Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

p53-independent mechanisms regulate the P2-MDM2 promoter in adult astrocytic tumours.

British journal of cancer - 7 Oct 2008

Dimitriadi M, Poulogiannis G, Liu L, Bäcklund L M, Pearson D M, Ichimura K, Collins V P

Abstract excerpt

The MDM2 gene is amplified and/or overexpressed in about 10% of glioblastomas and constitutes one of a number of ways the p53 pathway is disrupted in these tumours. MDM2 encodes a nuclear phosphoprotein that regulates several cell proteins by binding and/or ubiquitinating them, with p53 being a well-established partner. MDM2 has two promoters, P1 and P2 that give rise to transcripts with distinct 5' untranslated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Neoplasms
Share to Genotype
Share to Glioblastoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Promoter Regions, Genetic

Share to Proto-Oncogene Proteins c-mdm2

Share to Reverse Transcriptase Polymerase Chain Reaction

Share to RNA, Messenger

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 18781178
DOI: 10.1038/sj.bjc.6604643
PMCID: PMC2567066

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

p53-independent mechanisms regulate the P2-MDM2 promoter in adult astrocytic tumours.PMID 18781178Read ↗

Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations.Semantic proximity Read ↗

Identification of functional DNA variants in the constitutive promoter region of MDM2.Semantic proximity Read ↗

The role of a single nucleotide polymorphism of MDM2 in glioblastoma multiforme.Semantic proximity Read ↗

The Role of MDM2 Amplification and Overexpression in Tumorigenesis.Semantic proximity Read ↗

A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans.Semantic proximity Read ↗

A chromatin-associated and transcriptionally inactive p53-Mdm2 complex occurs in mdm2 SNP309 homozygous cells.Semantic proximity Read ↗

Influence of MDM2 SNP309 alone or in combination with the TP53 R72P polymorphism in oligodendroglial tumors.Semantic proximity Read ↗

Analysis of mdm2 and p53 gene alterations in glioblastomas and its correlation with clinical factors.Semantic proximity Read ↗

MDM2 promoter polymorphism SNP309 contributes to tumor susceptibility: evidence from 21 case-control studies.Semantic proximity Read ↗

The MDM2 gene amplification databaseSemantic proximity Read ↗

Impact of a single nucleotide polymorphism in the MDM2 gene on neuroblastoma development and aggressiveness: results of a pilot study on 239 patients.Semantic proximity Read ↗

Short alternative splice transcripts of the mdm2 oncogene correlate to malignancy in human astrocytic neoplasms.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.