Article
High-resolution deep sequencing reveals biodiversity, population structure, and persistence of HIV-1 quasispecies within host ecosystems.
Retrovirology - 17 Dec 2012
Yin Li, Liu Li, Sun Yijun, Hou Wei, Lowe Amanda C, Gardner Brent P, Salemi Marco, Williams Wilton B, Farmerie William G, Sleasman John W, Goodenow Maureen M
Abstract excerpt
BACKGROUND: Deep sequencing provides the basis for analysis of biodiversity of taxonomically similar organisms in an environment. While extensively applied to microbiome studies, population genetics studies of viruses are limited. To define the scope of HIV-1 population biodiversity within infected individuals, a suite of phylogenetic and population genetic algorithms was applied to HIV-1 envelope hypervariable...
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