Article
Every microsatellite is different: Intrinsic DNA features dictate mutagenesis of common microsatellites present in the human genome.
Molecular carcinogenesis - 1 Apr 2009
Eckert Kristin A, Hile Suzanne E
Abstract excerpt
Microsatellite sequences are ubiquitous in the human genome and are important regulators of genome function. Here, we examine the mutational mechanisms governing the stability of highly abundant mono-, di-, and tetranucleotide microsatellites. Microsatellite mutation rate estimates from pedigree analyses and experimental models range from a low of approximately 10(-6) to a high of approximately 10(-2) mutations...
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