Article
The sequence of the repetitive motif influences the frequency of multistep mutations in Short Tandem Repeats.
Scientific reports - 24 Jun 2023
Antão-Sousa Sofia, Pinto Nádia, Rende Pablo, Amorim António, Gusmão Leonor
Abstract excerpt
Microsatellites, or Short Tandem Repeats (STRs), are subject to frequent length mutations that involve the loss or gain of an integer number of repeats. This work aimed to investigate the correlation between STRs' specific repetitive motif composition and mutational dynamics, specifically the occurrence of single- or multistep mutations. Allelic transmission data, comprising 323,818 allele transfers and 1,297...
Topics
- Humans
- Mutation
- Genetics, Population
- Microsatellite Repeats
- Y Chromosome
- DNA Fingerprinting
- Alleles
- Gene Frequency
- Chromosomes, Human, Y