Article
Antioxidant enzymes reduce DNA damage and early activation of valvular interstitial cells in aortic valve sclerosis.
Arteriosclerosis, thrombosis, and vascular biology - 1 Feb 2013
Branchetti Emanuela, Sainger Rachana, Poggio Paolo, Grau Juan B, Patterson-Fortin Jeffrey, Bavaria Joseph E, Chorny Michael, Lai Eric, Gorman Robert C, Levy Robert J, Ferrari Giovanni
Abstract excerpt
OBJECTIVE: Accumulation of reactive oxygen species (ROS) and remodeling of the microstructure of the cusp characterize aortic valve sclerosis, the early phase of calcific aortic valve disease. These events are associated with activation of valvular interstitial cells (VICs) toward an osteogenic-like phenotype. Because ROS cause DNA damage and transcriptional activation we investigated the relationship between...
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