Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Radiation induces osteogenesis in human aortic valve interstitial cells.

The Journal of thoracic and cardiovascular surgery - 1 Dec 2012

Nadlonek Nicole A, Weyant Michael J, Yu Jessica A, Cleveland Joseph C, Reece T Brett, Meng Xianzhong, Fullerton David A

Abstract excerpt

OBJECTIVE: Irradiation of the chest or chest wall has been shown to cause calcific aortic stenosis. However, the mechanisms are unknown. Aortic valve interstitial cells have been implicated in the pathogenesis of aortic stenosis; they have been shown to change from the phenotype of a myofibroblast to an osteoblastlike cell. We therefore hypothesized that irradiation of human aortic valve interstitial cells...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aortic Valve
Share to Aortic Valve Stenosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bone Morphogenetic Protein 2

Share to Core Binding Factor Alpha 1 Subunit

Share to Osteogenesis

Share to Osteopontin

Share to Radiation Injuries

Share to Radiotherapy

Source

Open in PubMed Open full text

Identifiers

PMID: 23026565
DOI: 10.1016/j.jtcvs.2012.08.041
PMCID: PMC3665422

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Radiation induces osteogenesis in human aortic valve interstitial cells.PMID 23026565Read ↗

Antioxidant enzymes reduce DNA damage and early activation of valvular interstitial cells in aortic valve sclerosis.Semantic proximity Read ↗

Pro-osteogenic phenotype of human aortic valve interstitial cells is associated with higher levels of Toll-like receptors 2 and 4 and enhanced expression of bone morphogenetic protein 2.Semantic proximity Read ↗

Fibrocalcific Aortic Valve DiseaseSemantic proximity Read ↗

The progression of calcific aortic valve disease through injury, cell dysfunction, and disruptive biologic and physical force feedback loops.Semantic proximity Read ↗

Human aortic valve calcification is associated with an osteoblast phenotype.Semantic proximity Read ↗

Transcriptional regulation of heart valve development and disease.Semantic proximity Read ↗

Altered MicroRNA Expression Is Responsible for the Pro-Osteogenic Phenotype of Interstitial Cells in Calcified Human Aortic Valves.Semantic proximity Read ↗

Recruitment of bone marrow-derived valve interstitial cells is a normal homeostatic process.Semantic proximity Read ↗

Bench to bedside defining calcific aortic valve disease: osteocardiology.Semantic proximity Read ↗

Noggin attenuates the osteogenic activation of human valve interstitial cells in aortic valve sclerosis.Semantic proximity Read ↗

Notch1 represses osteogenic pathways in aortic valve cells.Semantic proximity Read ↗

Aortic calcified particles modulate valvular endothelial and interstitial cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.