Article
Neoangiogenesis, T-lymphocyte infiltration, and heat shock protein-60 are biological hallmarks of an immunomediated inflammatory process in end-stage calcified aortic valve stenosis.
Journal of the American College of Cardiology - 5 May 2004
Mazzone Annamaria, Epistolato Maria Carmela, De Caterina Raffaele, Storti Simona, Vittorini Simona, Sbrana Silverio, Gianetti Jacopo, Bevilacqua Stefano, Glauber Mattia, Biagini Andrea, Tanganelli Piero
Abstract excerpt
OBJECTIVES: We investigated the main biomolecular features in the evolution of aortic stenosis, focusing on advanced lesions. BACKGROUND: "Degenerative" aortic valve stenosis shares risk factors and inflammatory similarities with atherosclerosis. METHODS: We compared nonrheumatic stenotic aortic valves from 26 patients undergoing surgical valve replacement (group A) and 14 surgical control patients (group B). We...
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