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Article

Noggin attenuates the osteogenic activation of human valve interstitial cells in aortic valve sclerosis.

Cardiovascular research - 1 Jun 2013

Poggio Paolo, Sainger Rachana, Branchetti Emanuela, Grau Juan B, Lai Eric K, Gorman Robert C, Sacks Michael S, Parolari Alessandro, Bavaria Joseph E, Ferrari Giovanni

Abstract excerpt

AIMS: Aortic valve sclerosis (AVSc) is a hallmark of several cardiovascular conditions ranging from chronic heart failure and myocardial infarction to calcific aortic valve stenosis (AVS). AVSc, present in 25-30% of patients over 65 years of age, is characterized by thickening of the leaflets with marginal effects on the mechanical proprieties of the valve making its presentation asymptomatic. Despite its...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23483047
DOI: 10.1093/cvr/cvt055
PMCID: PMC3656614

Genes

BMP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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