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Article

Enhanced immunogenicity using an alphavirus replicon DNA vaccine against human immunodeficiency virus type 1

19 Jan 2005

Abstract excerpt

With the human immunodeficiency virus type 1 (HIV-1) epidemic expanding at increasing speed, development of a safe and effective vaccine remains a high priority. One of the most central vaccine platforms considered is plasmid DNA. However, high doses of DNA and several immunizations are typically needed to achieve detectable T-cell responses. In this study, a Semliki Forest virus replicon DNA vaccine designed for...

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Identifiers

PMID: 15659754
DOI: 10.1099/vir.0.80481-0

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