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Article

Intrinsic translocation barrier as an initial step in pausing by RNA polymerase II.

Journal of molecular biology - 22 Feb 2013

Imashimizu Masahiko, Kireeva Maria L, Lubkowska Lucyna, Gotte Deanna, Parks Adam R, Strathern Jeffrey N, Kashlev Mikhail

Abstract excerpt

Pausing of RNA polymerase II (RNAP II) by backtracking on DNA is a major regulatory mechanism in control of eukaryotic transcription. Backtracking occurs by extrusion of the 3' end of the RNA from the active center after bond formation and before translocation of RNAP II on DNA. In several documented cases, backtracking requires a special signal such as A/T-rich sequences forming an unstable RNA-DNA hybrid in the...

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Identifiers

PMID: 23238253
DOI: 10.1016/j.jmb.2012.12.002
PMCID: PMC7649676

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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