Article
Evidence that transcript cleavage is essential for RNA polymerase II transcription and cell viability.
Molecular cell - 23 Apr 2010
Sigurdsson Stefan, Dirac-Svejstrup A Barbara, Svejstrup Jesper Q
Abstract excerpt
During transcript elongation in vitro, backtracking of RNA polymerase II (RNAPII) is a frequent occurrence that can lead to transcriptional arrest. The polymerase active site can cleave the transcript during such backtracking, allowing transcription to resume. Transcript cleavage is either stimulated by elongation factor TFIIS or occurs much more slowly in its absence. However, whether backtracking actually...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.