Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

3′UTR-truncated Hmga2 cDNA causes MPN-like hematopoiesis by conferring a clonal growth advantage at the level of HSC in mice

2 Apr 2011

Abstract excerpt

Overexpression of high mobility group AT-hook 2 (HMGA2) is found in a number of benign and malignant tumors, including the clonal PIGA(-) cells in 2 cases of paroxysmal nocturnal hemoglobinuria (PNH) and some myeloproliferative neoplasms (MPNs), and recently in hematopoietic cell clones resulting from gene therapy procedures. In nearly all these cases overexpression is because of deletions or translocations that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Complement system in diseases
Share to Myeloproliferative Neoplasms: Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21460244
DOI: 10.1182/blood-2011-02-334425

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

3′UTR-truncated Hmga2 cDNA causes MPN-like hematopoiesis by conferring a clonal growth advantage at the level of HSC in micePMID 21460244Read ↗

Deregulated expression of <i>HMGA2</i> is implicated in clonal expansion of PIGA deficient cells in paroxysmal nocturnal haemoglobinuriaSemantic proximity Read ↗

The role of HMGA2 in the proliferation and expansion of a hematopoietic cell in myeloproliferative neoplasms.Semantic proximity Read ↗

Aberrant let7a/HMGA2 signaling activity with unique clinical phenotype in JAK2-mutated myeloproliferative neoplasms.Semantic proximity Read ↗

Human HMGA2 protein overexpressed in mice induces precursor T-cell lymphoblastic leukemia.Semantic proximity Read ↗

Molecular basis of clonal expansion of hematopoiesis in 2 patients with paroxysmal nocturnal hemoglobinuria (PNH).Semantic proximity Read ↗

High Mobility Group AT-Hook 2 (HMGA2) Oncogenicity in Mesenchymal and Epithelial NeoplasiaSemantic proximity Read ↗

Dysregulation of the <i><scp>MIRLET</scp>7</i>/<i><scp>HMGA</scp>2</i> axis with methylation of the <i><scp>CDKN</scp>2A</i> promoter in myeloproliferative neoplasmsSemantic proximity Read ↗

Overexpression of the HMGA2 gene in transgenic mice leads to the onset of pituitary adenomas.Semantic proximity Read ↗

Chromatin modifier Hmga2 promotes adult hematopoietic stem cell function and blood regeneration in stress conditionsSemantic proximity Read ↗

Misexpression of Full-length HMGA2 Induces Benign Mesenchymal Tumors in MiceSemantic proximity Read ↗

Mutation responsible for the mouse pygmy phenotype in the developmentally regulated factor HMGI-C.Semantic proximity Read ↗

Progressive genomic instability in the Nup98-HoxD13 model of MDS correlates with loss of the PIG-A gene product.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.