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Article

Dietary restriction improves intestinal cellular fitness to enhance gut barrier function and lifespan in D. melanogaster

1 Nov 2018

Abstract excerpt

Loss of gut integrity is linked to various human diseases including inflammatory bowel disease.However, the mechanisms that lead to loss of barrier function remain poorly understood.Using D. melanogaster, we demonstrate that dietary restriction (DR) slows the agerelated decline in intestinal integrity by enhancing enterocyte cellular fitness through up-regulation of dMyc in the intestinal epithelium.Reduction of...

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PMID: 30383748
DOI: 10.1371/journal.pgen.1007777

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