Article

Fat body CLOCK restrains innate immunity and maintains survival under dietary stress in <i>Drosophila</i>

2026-07-21

Abstract excerpt

<h4>SUMMARY</h4> Both aging and a high-fat diet (HFD) dampen circadian gene transcription rhythms and promote chronic inflammation. How aging and HFD interact to affect peripheral molecular clocks and circadian behavior remains unclear. Using Drosophila melanogaster , we showed that aging and HFD additively dampened circadian behavior, with their adverse effects converging on the fat body (FB), a tissue that reg...

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Literature Corpus work: 9b05b87d-cb13-5616-9a66-1d8a9fee3bde
DOI: 10.64898/2026.07.20.739608

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