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Article

Age-specific variation in immune response in Drosophila melanogaster has a genetic basis.

Genetics - 1 Jul 2012

Felix Tashauna M, Hughes Kimberly A, Stone Eric A, Drnevich Jenny M, Leips Jeff

Abstract excerpt

Immunosenescence, the age-related decline in immune system function, is a general hallmark of aging. While much is known about the cellular and physiological changes that accompany immunosenescence, we know little about the genetic influences on this phenomenon. In this study we combined age-specific measurements of bacterial clearance ability following infection with whole-genome measurements of the...

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Identifiers

PMID: 22554890
DOI: 10.1534/genetics.112.140640
PMCID: PMC3389989

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