Article
Toll-like receptor (TLR) 2 mediates inflammatory responses to oligomerized RrgA pneumococcal pilus type 1 protein.
The Journal of biological chemistry - 25 Jan 2013
Basset Alan, Zhang Fan, Benes Cyril, Sayeed Sabina, Herd Muriel, Thompson Claudette, Golenbock Douglas T, Camilli Andrew, Malley Richard
Abstract excerpt
The pneumococcal type 1 pilus is an inflammatory and adherence-promoting structure associated with increased virulence in mouse models. We show that RrgA, an ancillary pilus subunit devoid of a lipidation motif, particularly when presented as part of an oligomer, is a TLR2 agonist. The surface-exposed domain III, and in particular a 49-amino acid sequence (P3), of the protein is responsible for the TLR2 activity...
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