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Article

Pneumococcal peptidoglycan-polysaccharides regulate Toll-like receptor 2 in the mouse middle ear epithelial cells.

Pediatric research - 1 Feb 2011

Komori Masahiro, Nakamura Yoshihisa, Ping Jesse, Feng Ling, Toyama Katsuhiro, Kim Youngki, Ferrieri Patricia, Lin Jizhen

Abstract excerpt

Toll-like receptor 2 (TLR2) plays a key role in the host defense against Gram staining positive (Gram) bacteria and their cell wall envelope components. However, little is known about the expression of TLR2 in the middle ear under otitis media (OM) conditions, and its role in the persistent otitis media with effusion (OME). In this study, we demonstrated that the pneumococcal cell wall component,...

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Identifiers

PMID: 21076367
DOI: 10.1203/PDR.0b013e3182055237
PMCID: PMC3020247

Genes

TLR2

Provenance

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