Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Assessing telomeric DNA content in pediatric cancers using whole-genome sequencing data

11 Dec 2012

Abstract excerpt

BACKGROUND: Telomeres are the protective arrays of tandem TTAGGG sequence and associated proteins at the termini of chromosomes. Telomeres shorten at each cell division due to the end-replication problem and are maintained above a critical threshold in malignant cancer cells to prevent cellular senescence or apoptosis. With the recent advances in massive parallel sequencing, assessing telomere content in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Epigenetics and DNA Methylation
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23232254
DOI: 10.1186/gb-2012-13-12-r113

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Assessing telomeric DNA content in pediatric cancers using whole-genome sequencing dataPMID 23232254Read ↗

Molecular Mechanism of Telomere Length Dynamics and Its Prognostic Value in Pediatric Cancers.Semantic proximity Read ↗

Neotelomeres and telomere-spanning chromosomal arm fusions in cancer genomes revealed by long-read sequencingSemantic proximity Read ↗

Neotelomeres and Telomere-Spanning Chromosomal Arm Fusions in Cancer Genomes Revealed by Long-Read SequencingSemantic proximity Read ↗

A NOVEL MACHINE LEARNING APPROACH FOR TUMOR DETECTION BASED ON TELOMERIC SIGNATURESSemantic proximity Read ↗

Genomic footprints of activated telomere maintenance mechanisms in cancer.Semantic proximity Read ↗

Alternative lengthening of telomeres (ALT) in pediatric high-grade gliomas can occur without ATRX mutation and is enriched in patients with pathogenic germline mismatch repair (MMR) variants.Semantic proximity Read ↗

Genomic footprints of activated telomere maintenance mechanisms in cancerSemantic proximity Read ↗

TelomereHunter – in silico estimation of telomere content and composition from cancer genomesSemantic proximity Read ↗

Telomere content and genomics of myeloid neoplasia by whole-genome sequencing.Semantic proximity Read ↗

Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing dataSemantic proximity Read ↗

The ALT pathway generates telomere fusions that can be detected in the blood of cancer patientsSemantic proximity Read ↗

Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.