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Article

Molecular Mechanism of Telomere Length Dynamics and Its Prognostic Value in Pediatric Cancers.

Journal of the National Cancer Institute - 1 Jul 2020

Wang Zhaoming, Rice Stephen V, Chang Ti-Cheng, Liu Yu, Liu Qi, Qin Na, Putnam Daniel K, Shelton Kyla, Lanctot Jennifer Q, Wilson Carmen L, Ness Kirsten K, Rusch Michael C, Edmonson Michael N, Wu Gang, Easton John, Kesserwan Chimene A, Downing James R, Chen Xiang, Nichols Kim E, Yasui Yutaka, Robison Leslie L, Zhang Jinghui

Abstract excerpt

BACKGROUND: We aimed to systematically evaluate telomere dynamics across a spectrum of pediatric cancers, search for underlying molecular mechanisms, and assess potential prognostic value. METHODS: The fraction of telomeric reads was determined from whole-genome sequencing data for paired tumor and normal samples from 653 patients with 23 cancer types from the Pediatric Cancer Genome Project. Telomere dynamics...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31647544
DOI: 10.1093/jnci/djz210
PMCID: PMC7357329

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