Article
Telomere content and genomics of myeloid neoplasia by whole-genome sequencing.
Blood - 8 Jan 2026
Guarnera Luca, Wahida Adam, Gurnari Carmelo, Hutter Stephan, Stainczyk Sabine A, Williams Nakisha D, Durmaz Arda, Kubota Yasuo, Bravo-Perez Carlos, Kawashima Naomi, Orland Mark, Pagliuca Simona, Huang Yimin, LaFramboise Thomas, Visconte Valeria, Walter Wencke, Meggendorfer Manja, Kern Wolfgang, Westermann Frank, Feuerbach Lars, Haferlach Torsten, Maciejewski Jaroslaw P
Abstract excerpt
ABSTRACT: Telomere length shortening has been associated with genomic instability and acquisition of molecular lesions, but these processes have not been systematically studied across large cohorts of myeloid neoplasia (MN). As proof of concept for a novel, cross-validated whole-genome sequencing-based method of telomere content (TC) determination combined with mutations, transcriptomics, and functional assays,...
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