Article
Catechol-O-methyltransferase val158met and cognitive function in Parkinson's disease.
Movement disorders : official journal of the Movement Disorder Society - 15 Nov 2010
Hoogland Jeroen, de Bie Rob M A, Williams-Gray Caroline H, Muslimović Dino, Schmand Ben, Post Bart
Abstract excerpt
Cognitive dysfunction is one of the most incapacitating non-motor symptoms of Parkinson's disease (PD). Some cognitive deficits are thought to be related to abnormal dopamine homeostasis. The latter is influenced by catechol-O-methyltransferase (COMT), an enzyme that degrades dopamine. Previous research suggests a relationship between the COMT val158met functional polymorphism (SNP) and measures of executive...
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