Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The adaptor protein Grb2 is not essential for the establishment of the glomerular filtration barrier.

PloS one - 1 Jan 2012

Bisson Nicolas, Ruston Julie, Jeansson Marie, Vanderlaan Rachel, Hardy W Rod, Du Jianmei, Hussein Samer M, Coward Richard J, Quaggin Susan E, Pawson Tony

Abstract excerpt

The kidney filtration barrier is formed by the combination of endothelial cells, basement membrane and epithelial cells called podocytes. These specialized actin-rich cells form long and dynamic protrusions, the foot processes, which surround glomerular capillaries and are connected by specialized intercellular junctions, the slit diaphragms. Failure to maintain the filtration barrier leads to massive proteinuria...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Crosses, Genetic
Share to Gene Silencing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GRB2 Adaptor Protein

Share to Integrases

Share to Intracellular Signaling Peptides and Proteins

Share to Mice, Knockout

Share to Organ Specificity

Share to Podocytes

Source

Open in PubMed Open full text

Identifiers

PMID: 23226445
DOI: 10.1371/journal.pone.0050996
PMCID: PMC3511449

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The adaptor protein Grb2 is not essential for the establishment of the glomerular filtration barrier.PMID 23226445Read ↗

The tricellular junctional protein Ildr2 helps maintain glomerular podocyte architectureSemantic proximity Read ↗

Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes.Semantic proximity Read ↗

Crk1/2 and CrkL form a hetero-oligomer and functionally complement each other during podocyte morphogenesis.Semantic proximity Read ↗

CD2AP is expressed with nephrin in developing podocytes and is found widely in mature kidney and elsewhere.Semantic proximity Read ↗

CD2-associated protein and glomerular disease.Semantic proximity Read ↗

Glomerular structure and function require paracrine, not autocrine, VEGF-VEGFR-2 signaling.Semantic proximity Read ↗

beta-Catenin mediates adriamycin-induced albuminuria and podocyte injury in adult mouse kidneys.Semantic proximity Read ↗

CIN85/RukL Is a Novel Binding Partner of Nephrin and Podocin and Mediates Slit Diaphragm Turnover in PodocytesSemantic proximity Read ↗

Dystroglycan does not contribute significantly to kidney development or function, in health or after injurySemantic proximity Read ↗

Interaction of Endogenous Nephrin and CD2-Associated Protein in Mouse Epithelial M-1 Cell LineSemantic proximity Read ↗

Loss of ezrin expression reduced the susceptibility to the glomerular injury in mice.Semantic proximity Read ↗

Gene structure and functional analysis of the mouse nidogen-2 gene: nidogen-2 is not essential for basement membrane formation in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.