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Article

Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes.

Nature - 6 Apr 2006

Jones Nina, Blasutig Ivan M, Eremina Vera, Ruston Julie M, Bladt Friedhelm, Li Hongping, Huang Haiming, Larose Louise, Li Shawn S-C, Takano Tomoko, Quaggin Susan E, Pawson Tony

Abstract excerpt

The glomerular filtration barrier in the kidney is formed in part by a specialized intercellular junction known as the slit diaphragm, which connects adjacent actin-based foot processes of kidney epithelial cells (podocytes). Mutations affecting a number of slit diaphragm proteins, including nephrin (encoded by NPHS1), lead to renal disease owing to disruption of the filtration barrier and rearrangement of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16525419
DOI: 10.1038/nature04662

Genes

NPHS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes.PMID 16525419Read ↗

Nck Links Nephrin to Actin in Kidney PodocytesSemantic proximity Read ↗

Phosphorylated YDXV Motifs and Nck SH2/SH3 Adaptors Act Cooperatively To Induce Actin ReorganizationSemantic proximity Read ↗

Nephrin Signaling in the Podocyte: An Updated View of Signal Regulation at the Slit Diaphragm and BeyondSemantic proximity Read ↗

Revisiting nephrin signaling and its specialized effects on the uniquely adaptable podocyteSemantic proximity Read ↗

Interaction with Podocin Facilitates Nephrin SignalingSemantic proximity Read ↗

Nephrin Signaling Results in Integrin β1 ActivationSemantic proximity Read ↗

A critical role of the podocyte cytoskeleton in the pathogenesis of glomerular proteinuria and autoimmune podocytopathiesSemantic proximity Read ↗

An update: the role of Nephrin inside and outside the kidneySemantic proximity Read ↗

Rat nephrin modulates cell morphology via the adaptor protein NckSemantic proximity Read ↗

Nephrin – a unique structural and signaling protein of the kidney filterSemantic proximity Read ↗

Nephrin-signature molecule of the glomerular podocyte?Semantic proximity Read ↗

IQGAP1 regulates actin cytoskeleton organization in podocytes through interaction with nephrinSemantic proximity Read ↗

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