Article
beta-Catenin mediates adriamycin-induced albuminuria and podocyte injury in adult mouse kidneys.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 Aug 2010
Heikkilä Eija, Juhila Juuso, Lassila Markus, Messing Marcel, Perälä Nina, Lehtonen Eero, Lehtonen Sanna, Sjef Verbeek Joseph, Holthofer Harry
Abstract excerpt
BACKGROUND: Glomerular slit diaphragm (SD) represents a modified adherens junction composed of molecules belonging to both immunoglobulin and cadherin superfamilies. Cadherins associate with the cytosolic scaffolding protein beta-catenin, but the precise role of beta-catenin in mature or injured podocytes is not known. METHODS: The conditional podocyte-specific beta-catenin-deficient mouse line was generated...
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